Extracellular matrix remodeling pathway

The extracellular matrix remodeling pathway encompasses the tightly regulated processes of ECM synthesis, post-translational modification, degradation, and reorganization, mediated by a large variety of enzymes including matrix metalloproteinases (MMPs), lysyl oxidases, heparanase, cathepsins, and others. ECM remodeling is critical for normal physiological events such as embryonic development, wound healing, and tissue homeostasis. Dysregulation of ECM remodeling contributes to pathological conditions including cancer metastasis, fibrosis, and chronic inflammatory diseases. Unlike a single molecular target, this pathway involves numerous interacting proteins, making it a challenging but promising area for developing novel therapeutics aiming to modulate tissue structure, cell signaling, and disease progression.

Other names

ECM remodeling pathwayextracellular matrix remodelingECM turnover

Individual drugs act by inhibiting ECM-modifying enzymes, such as matrix metalloproteinases (MMPs), heparanase, and others.