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Extracellular Matrix Stabilization (ECM Stabilization)
- Target
- ECM Stabilization
- Molecular classification
- Extracellular matrix, Structural protein, Enzyme, Proteoglycan, Glycosaminoglycan
01
Overview
Extracellular matrix stabilization encompasses all molecular events that preserve or reinforce the structure-function relationship within tissues through balanced synthesis/degradation/crosslinking activities involving multiple macromolecules and regulatory proteins. It involves the maintenance or enhancement of the structural integrity, mechanical properties, and functional organization of the extracellular matrix (ECM) in tissues.
02
Mechanism of action
N/A
03
Biological functions
Structural supportTissue homeostasisCell adhesionGrowth factor sequestrationRegulation of cell proliferationRegulation of cell migrationRegulation of cell differentiationRegulation of cell survivalRegulation of apoptosisMechanical signal transduction
04
Disease associations
Tissue fragilityImpaired wound healingFibrosisTumor invasionMetastasisCancer
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