Extracellular matrix structural component (ECM structural component)

The term Extracellular matrix (ECM) structural component refers to a broad functional category of proteins and polysaccharides that provide the physical scaffolding and biochemical signaling environment for cells within tissues. Key components include fibrous proteins like collagens and elastins, as well as adhesive glycoproteins such as fibronectin and laminin. In a therapeutic context, this is considered a broad class rather than a single target, as it encompasses hundreds of distinct molecules that regulate cell behavior, migration, and tissue integrity (Source: Gene Ontology GO:0005198; PMID: 22345513). Dysregulation of ECM structural components is a hallmark of various pathologies, including systemic fibrosis, where excessive collagen deposition leads to organ failure, and cancer, where a stiffened ECM promotes tumor progression and limits drug delivery (Source: PMID: 30111884). While specific enzymes that modify the ECM (like MMPs or LOX) are frequent drug targets, the structural components themselves are often targeted via degradative enzymes or by inhibiting their assembly to treat conditions like Dupuytren's contracture or to enhance the penetration of oncology therapeutics (Source: PMID: 28930665).

Other names

Extracellular matrix proteinECM proteinMatrisome component

Degradation of structural components to reduce tissue stiffness or improve drug penetration; inhibition of synthesis or cross-linking to treat fibrosis.