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Target intelligence / Profile preview
Extracellular Matrix Structural Proteins (ECM Structural Proteins)
- Target
- ECM Structural Proteins
- Molecular classification
- Structural Protein, Extracellular Matrix Component, Glycoprotein, Proteoglycan
01
Overview
Extracellular matrix (ECM) structural proteins are a group of macromolecules that form the essential scaffold surrounding and supporting cells within tissues and organs. These proteins provide mechanical strength and regulate cell behavior, tissue development, and homeostasis. Key structural proteins include collagens, elastin, fibronectin, laminins, and tenascins. They mediate signaling through interactions with receptors like integrins, discoidin domain receptors and syndecans. Mutations or dysregulation can lead to various diseases and ECM remodeling is central to cancer progression, metastasis, wound healing and fibrosis.
- Other names
- ECM ProteinsStructural ECM Components
02
Biological functions
Mechanical support to tissuesRegulation of cell proliferationRegulation of cell differentiationRegulation of cell migrationRegulation of cell survivalCell adhesionTissue developmentWound healingTissue repairHomeostasisSignaling
03
Disease associations
Connective tissue disordersOsteogenesis imperfectaEhlers-Danlos syndromeCutis laxaAortic aneurysmsCancer progressionMetastasisWound healingFibrosis
04
Safety considerations
Off-target effects on other ECM componentsPotential for immune responseDisruption of tissue homeostasisUnintended effects on cell signaling
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