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Extracellular matrix volume replacement
- Molecular classification
- Extracellular matrix, Structural protein, Glycosaminoglycan
01
Overview
Extracellular matrix volume replacement refers to the restoration or augmentation of the non-cellular component within tissues and organs, essential for structural support, intercellular communication, and influencing cellular behavior. It's crucial in wound healing, fibrosis, and cardiac applications. Approaches involve biomaterial scaffolds and hydrogels to mimic the native ECM.
02
Mechanism of action
Biomaterial scaffolds/hydrogels that mimic the native ECM, promoting tissue regeneration and restoring tissue architecture/function.
03
Biological functions
Structural supportCell adhesionCell migrationCell proliferationCell differentiationGrowth factor sequestrationTissue homeostasisWound healing
04
Disease associations
Wound healingFibrosisDegenerative diseasesCardiac remodelingMyocardial fibrosisHeart failure
05
Safety considerations
Uncontrolled matrix degradationExcessive matrix depositionImmune response to biomaterialsOff-target effects on cellular behavior
06
Biomarkers
Extracellular volume fraction (ECV) via cardiac MRI
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