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The extracellular pH buffering system is a complex system of chemical buffers, primarily the bicarbonate/carbonic acid system, that maintains a stable pH in the extracellular fluid. This system is crucial for proper cellular function and overall metabolic homeostasis. It resists changes in pH by reversibly binding hydrogen ions. The system is influenced by both respiratory and renal mechanisms that affect CO2 and bicarbonate levels, respectively. Dysregulation can lead to acid-base imbalances, affecting various physiological processes.
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