Extracellular phosphorylated substrates (EPS)

Extracellular phosphorylated substrates refer to a broad and diverse group of proteins that undergo phosphorylation within the secretory pathway or in the extracellular space, primarily by kinases such as FAM20C (the Golgi casein kinase) and VLK (Vertebrate Lonesome Kinase). These substrates include critical proteins involved in bone and tooth mineralization, such as the SIBLING (Small Integrin-Binding Ligand N-linked Glycoprotein) family, as well as various hormones and clotting factors. Because this term describes a collective state of many different proteins rather than a single molecular entity, it is not considered a specific therapeutic target in the traditional sense. Instead, the enzymes responsible for these modifications or the specific individual phosphoproteins themselves are typically the focus of drug discovery and clinical research. Disruption in the phosphorylation of these substrates is linked to various pathologies, including Raine syndrome, biomineralization defects, and potentially certain types of cancer progression.

Other names

Secreted phosphoproteinsExtracellular phosphoproteomePhosphorylated secreted proteins

Not applicable as this is a broad category of molecules rather than a single drug target.