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Biofilm
- Molecular classification
- Complex Microbial Community, Extracellular Matrix
01
Overview
A biofilm is an aggregate of microorganisms in which cells adhere to each other and often to a surface, embedded within a self-produced matrix of extracellular polymeric substances (EPS). This matrix acts as a scaffold, providing structural stability and protection for the microbial community. Biofilms can form on both living (biotic) and non-living (abiotic) surfaces in diverse environments.
- Other names
- Microbial aggregateExtracellular polymeric substance matrix
02
Mechanism of action
N/A. Biofilm is a complex structure, not a single molecule with a specific mechanism of action. Anti-biofilm agents target various aspects of biofilm formation or disrupt the EPS matrix.
03
Biological functions
Surface adhesionNutrient cyclingQuorum sensingGenetic material exchangeMetabolic cooperationProtection from environmental stresses
04
Disease associations
Chronic infectionsDental plaque formationMedical device-related infectionsIndustrial foulingBiofilm-associated diseases
05
Safety considerations
Antibiotic resistanceDifficult to eradicateSource of persistent or recurrent infectionsPotential for systemic spread of infectionTolerance to disinfectants
06
Interacting drugs
Antibiotics
2 more in the full profile.
07
Biomarkers
Biofilm presence (e.g., via microscopy, culture)EPS componentsSpecific microbial species within the biofilm
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