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Target intelligence / Profile preview
Extracellular RNA (exRNA)
- Target
- exRNA
- Molecular classification
- RNA, mRNA, lncRNA, miRNA, piRNA, siRNA, tRNA-derived fragments, Y RNA, circRNA
01
Overview
Extracellular RNA (exRNA) refers to various RNA species found outside cells, protected by encapsulation within extracellular vesicles or association with lipoprotein particles/ribonucleoprotein complexes. ExRNAs mediate intercellular communication, regulate gene expression, and are implicated in various diseases, making them promising biomarkers and therapeutic targets.
- Other names
- circulating RNAcell-free RNAsecreted RNA
02
Mechanism of action
Engineered exRNAs could serve as targeted treatments for diseases, modulating gene expression in recipient cells through mechanisms like RNA interference.
03
Biological functions
Intercellular signalingIntercellular communicationRegulation of gene expressionModulation of biological processesAngiogenesisImmune response modulationMetabolism regulationBlood cell differentiationDevelopment patterning
04
Disease associations
CancerInflammationInfectionNeurodegenerative diseasesCardiovascular diseases
05
Safety considerations
Off-target effectsImmune response to delivery vehiclesUnintended consequences of gene expression modulation
06
Biomarkers
Diagnostic biomarkersPrognostic biomarkersBiomarkers for disease detectionLiquid biopsy markers
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