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Target intelligence / Profile preview
Extracellular signal-regulated kinase 8 (ERK8)
- Target
- ERK8
- Molecular classification
- Enzyme, Kinase, MAPK
01
Overview
Extracellular signal-regulated kinase 8 (ERK8), also known as MAPK15, is a member of the mitogen-activated protein kinase (MAPK) family. It plays diverse roles in cellular processes, including cell adhesion, cell cycle control, and apoptosis. ERK8 uniquely interacts with nuclear receptors like ERRα, acting as a corepressor. It's implicated in protecting genomic integrity, regulating glycosylation, and influences organelle dynamics. Aberrant ERK8 function has been linked to cancers such as breast and colon cancer, suggesting a complex role as both an oncogene and tumor suppressor depending on the cellular context. Its unique structural features offer opportunities for selective small-molecule inhibitor development.
- Other names
- MAPK15Mitogen-activated protein kinase 15ERK7
02
Mechanism of action
Kinase inhibition
03
Biological functions
Cell adhesionCell spreadingChemotaxisCell cycle progressionDifferentiationApoptosisPrimary cilium formationNuclear receptor regulationGenomic integrityRegulation of telomerase activityAutophagyRegulation of O-GalNAc glycosylation
04
Disease associations
CancerBreast cancerColon cancer
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