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Target intelligence / Profile preview
Mitogen-activated protein kinase pathway ERK1/2 (MAPK/ERK pathway)
- Target
- MAPK/ERK pathway
- Molecular classification
- Kinase/Enzyme, Signaling pathway
01
Overview
The Mitogen-activated protein kinase pathway ERK1/2 is a critical signaling cascade involved in cell growth, division, differentiation, and survival. It is activated by growth factors binding to cell surface receptors, initiating a cascade from Ras to Raf, MEK, and finally ERK1/2. This pathway plays a central role in tumorigenesis and is a target for cancer therapy. It is also involved in other diseases, including inflammation and neurodegenerative conditions.
- Other names
- ERK signaling pathwayRas-Raf-MEK-ERK pathwayExtracellular signal-regulated kinase pathway
02
Mechanism of action
Inhibition of MEK or Raf to block the ERK pathway\nActivation or inhibition of upstream receptors (e.g., receptor tyrosine kinases) to modulate the pathway
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalApoptosis regulationMetabolism regulationCell cycle progression
04
Disease associations
CancerInflammationNeurodegenerative diseases
05
Safety considerations
Potential for off-target effects on other signaling pathwaysSkin toxicity and other side effects associated with pathway inhibition
06
Interacting drugs
Various kinase inhibitors (e.g., MEK inhibitors like trametinib and cobimetinib, Raf inhibitors like vemurafenib)
07
Biomarkers
Phosphorylation levels of ERK1/2 or downstream targets
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