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Extracellular Signal-Regulated Kinase Signaling Pathway
- Molecular classification
- Mitogen Activated Protein Kinase (MAP kinase/MAPK), Signaling Pathway
01
Overview
The extracellular signal-regulated kinase (ERK) signaling pathway, also known as the MAPK/ERK pathway, is a conserved intracellular signaling cascade that transmits signals from extracellular stimuli to regulate diverse cellular processes. ERKs are serine/threonine protein kinases and are part of the mitogen-activated protein kinase (MAPK) family. The pathway is typically initiated by activation of receptor tyrosine kinases (RTKs) activating Ras which activates Raf kinases, which then phosphorylate and activate MEK1/2, which in turn phosphorylates ERK1/2.
02
Mechanism of action
Inhibition of pathway components (e.g., MEK inhibitors)
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survival/apoptosisCell cycle progressionCell migrationMetabolism
04
Disease associations
CancerCardiovascular diseaseNeurological disordersChronic inflammationArthritis
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Safety considerations
On-target toxicities due to broad expressionResistance mechanisms
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