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Exosome (N/A)
- Target
- N/A
- Molecular classification
- Vesicle, Extracellular Vesicle
01
Overview
Exosomes are small, membrane-bound extracellular vesicles (EVs) produced by most eukaryotic cells, typically ranging from 30 to 150 nanometers in diameter. They originate from the endosomal compartment of cells and are released into the extracellular environment through exocytosis. Exosomes carry a diverse array of biomolecules, including proteins, lipids, and nucleic acids, and mediate intercellular communication, influence recipient cell behavior, participate in immune responses, and serve as biomarkers for disease diagnosis. Engineered exosomes are being explored for therapeutic applications, such as drug and gene delivery.
- Other names
- Extracellular Vesicle (EV)Intraluminal Vesicle (ILV)
02
Mechanism of action
N/A
03
Biological functions
Intercellular communicationImmune modulationWaste removalCargo transportSignaling
04
Disease associations
CancerInflammationNeurodegenerative diseaseInfectionCardiovascular diseaseBiomarker for various diseases
05
Safety considerations
Potential for off-target delivery of engineered exosomesImmunogenicity of exosomesRisk of exacerbating disease through exosome-mediated transfer of pathogenic cargo
06
Biomarkers
Exosomal proteins (e.g., CD9, CD63, CD81, Alix, TSG101)Exosomal miRNAsExosomal DNA
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