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Extracellular vesicle-mediated intercellular communication (EV-mediated communication)
- Target
- EV-mediated communication
- Molecular classification
- Other
01
Overview
Extracellular vesicle (EV)-mediated intercellular communication is a process by which cells exchange information through the release and uptake of membrane-bound vesicles. EVs carry a diverse array of bioactive molecules—including proteins, nucleic acids, lipids, and metabolites—between cells, thereby influencing recipient cell behavior in both physiological and pathological contexts. This communication is involved in various biological functions and is implicated in multiple diseases, making it a potential therapeutic target and source of biomarkers.
- Other names
- Extracellular vesicle signalingEV-mediated signalingExosome communicationMicrovesicle communicationIntercellular communication via EVs
02
Mechanism of action
Modulation of EV biogenesis, release, uptake, or cargo; interference with EV interactions with target cells
03
Biological functions
Cell signalingImmune modulationInflammation regulationTissue repairDevelopmental processesMetabolic regulationGene expression modulationSignal transduction
04
Disease associations
CancerNeurological disordersCardiovascular diseasesInfectionsInflammationOther
05
Safety considerations
Off-target effects due to non-specific EV targetingPotential for immune responses against engineered EVsChallenges in controlling EV biodistribution and cargo deliveryComplexity of EV isolation and characterizationReproducibility of EV-based therapies
06
Biomarkers
EV protein contentEV mRNA contentEV microRNA contentEV lipid compositionEV surface markers
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