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Target intelligence / Profile preview
Extracellular Vesicles (EVs)
- Target
- EVs
- Molecular classification
- Lipid-enclosed particles, Membrane vesicles
01
Overview
Extracellular vesicles (EVs) are lipid-enclosed particles actively released by cells, functioning as key mediators of intercellular communication. They carry a diverse cargo of proteins, nucleic acids (including mRNA and miRNA), and lipids that can modulate the behavior of recipient cells. EVs influence cell migration and differentiation by affecting directional sensing, cell adhesion, ECM degradation, and lineage-specific differentiation pathways. Targeting EV-mediated pathways offers potential strategies for modulating pathological processes and enhancing regenerative medicine approaches.
- Other names
- ExosomesMicrovesiclesEctosomessEVs (small extracellular vesicles)
02
Mechanism of action
Modulation of cell signaling pathways via cargo delivery (proteins, mRNAs, miRNAs, lipids) and subsequent alteration of gene expression programs.
03
Biological functions
Intercellular communicationCell migration modulationCell differentiation modulationECM remodelingSignal transductionCargo delivery
04
Disease associations
Cancer metastasisVascular restenosisWound healingImmune responseTissue developmentRegenerative medicine
05
Safety considerations
Off-target effects due to non-specific uptakePotential for immune responseChallenges in controlled delivery and targeting
06
Biomarkers
EV-associated miRNAsEV protein content
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