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Target intelligence / Profile preview
Extradomain B Fibronectin (ED-B FN)
- Target
- ED-B FN
- Molecular classification
- Extracellular Matrix Glycoprotein, Oncofetal Antigen
01
Overview
Extradomain B fibronectin (ED-B FN) is a specific isoform of fibronectin arising from alternative splicing. It is minimally expressed in healthy adult tissues but is re-expressed during tumorigenesis, neoangiogenesis, and wound healing. It plays roles in angiogenesis, ECM assembly, and cell adhesion/migration, making it a therapeutic target for cancer.
- Other names
- Extra-domain B FibronectinEDB-FNEIIIB
02
Mechanism of action
Selective drug delivery to tumors
03
Biological functions
Angiogenesis supportECM assemblyCell adhesionCell migrationTube formationEndothelial cell proliferationNeovascularizationVEGF expression
04
Disease associations
CancerWound healing
05
Safety considerations
Limited accessibility when embedded within dense ECM structures typical in solid tumorsOn-target, off-tumor toxicity due to expression in embryonic tissues
06
Biomarkers
Tumor vasculature
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