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F-actin-capping protein subunit alpha-1 (CAPZA1)
- Target
- CAPZA1
- Molecular classification
- Actin binding protein, Cytoskeletal regulator, Other (not enzyme, receptor, transporter, ion channel, or transcription factor)
01
Overview
F-actin-capping protein subunit alpha-1 (CAPZA1) is a cytoskeletal protein that regulates actin filament growth by binding to the fast-growing (barbed) ends of actin filaments in a calcium-independent manner, blocking subunit exchange and preventing further filament assembly. Unlike severing proteins such as gelsolin, CAPZA1 does not break filaments but acts to stabilize their length and organization. It is implicated in the formation of epithelial cell junctions and the regulation of molecular motor complexes like dynactin for intracellular transport. Mutations in CAPZA1 have been associated with certain muscular and kidney diseases, but it is not considered a current therapeutic target or biomarker.
- Other names
- CAPZA1Cap Z alpha-1F-actin-capping protein subunit alpha-1CAZ1Capping actin protein of muscle Z-line subunit alpha 1CAPPA1Capping protein (actin filament) muscle Z-line, alpha 1Capping actin protein of muscle Z-line alpha subunit 1Capza1 (mouse ortholog)
02
Mechanism of action
Not applicable. There are no drugs with a recognized mechanism of action targeting CAPZA1.
03
Biological functions
Regulation of actin filament growth via barbed-end cappingControl of cytoskeletal organizationModulation of cell junction formationRegulation of endosomal trafficking and F-actin density around endocytic vesicles
04
Disease associations
Focal segmental glomerulosclerosis 1Nemaline myopathyOther (dysfunction linked to cytoskeletal disorders; limited direct clinical targeting)
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