F-actin polymerization in neutrophils

F-actin polymerization in neutrophils describes the rapid assembly of actin filaments (F-actin) from monomeric actin (G-actin) in response to receptor-mediated signals, such as chemoattractant gradients. This cytoskeletal remodeling underlies neutrophil shape change, directional migration (chemo-taxis), and is essential for efficient pathogen clearance by the innate immune system. The process is spatially and temporally regulated by upstream signaling cascades involving G protein-coupled receptors, small Rho-family GTPases (e.g., Cdc42, Rac), phosphoinositide signaling, and actin nucleating factors like the Arp2/3 complex and formins. Modulation of this process is fundamental to both normal immune responses and inflammatory disease pathogenesis.

Other names

Actin filament polymerization in neutrophilsNeutrophil actin assemblyNeutrophil cytoskeletal rearrangementNeutrophil actin remodeling

Inhibition of actin filament elongation (cytochalasins, latrunculins); Stabilization of actin filaments (jasplakinolide); Inhibition of actin nucleation (Arp2/3, formin inhibitors)