F-box and WD repeat domain containing protein 10B (FBXW10B)

F-box and WD repeat domain containing protein 10B (FBXW10B) is a member of the F-box protein family, characterized by the presence of an F-box domain and several WD repeat domains. F-box proteins are generally components of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates ubiquitination and proteasomal degradation of protein substrates. The specific biological function of FBXW10B remains uncharacterized. The gene is annotated as a putative pseudogene, and direct evidence for its involvement as a functional protein or as a validated drug target is lacking. Genomic location of FBXW10B is associated with the CMT1A repeat region on chromosome 17, which is duplicated in Charcot-Marie-Tooth disease type 1A. There are currently no known drugs, drug mechanisms, or established biomarker roles for this gene. Its inclusion in biomarker panels or therapeutic contexts appears unsupported; thus, it is not considered a bona fide therapeutic target[1][2][4][7].

Other names

CDRT1HREPSM25H2F-box and WD repeat domain containing 10 pseudogene 1F-box and WD-40 domain protein 10 pseudogene 1CMT1A duplicated region transcript 1 proteinC17orf1C17orf1AFBXW10P1