F-box and WD repeat domain-containing protein 5 (FBXW5)

F-box and WD repeat domain-containing protein 5 (FBXW5) is a member of the F-box protein family and acts as a substrate recognition module within the SCF (SKP1–CUL1–F-box protein) E3 ubiquitin ligase complex. FBXW5 specifically contains both an F-box motif and WD40 repeats, which enable its binding specificity for certain substrates such as SASS6, SEC23B, TSC2, and LATS1, leading to their ubiquitination and subsequent proteasomal degradation. Through these activities, FBXW5 is involved in the regulation of the cell cycle (e.g., preventing centriole reduplication), autophagy, and key signaling pathways such as the Hippo pathway, impacting cell proliferation, migration, apoptosis, and tumorigenesis. FBXW5 is considered a potential therapeutic target—particularly in oncology—due to its roles in cancer cell proliferation, metastasis, and drug resistance. No direct targeting agents or inhibitors are currently in clinical use.

Other names

F-box/WD repeat-containing protein 5F-box and WD repeat domain containing 5FBW5Fbw5DKFZP434B205PP3971MGC20962WD repeat-containing F-box protein FBW5F-box and WD-40 domain-containing protein 5

Not applicable (as there are currently no known drugs acting directly on FBXW5; mechanistically, inhibition or modulation would likely impact ubiquitination of substrates such as LATS1, SASS6, TSC2, SEC23B)