F-box DNA helicase 1 (FBH1)

F-box DNA helicase 1 (FBH1) is a unique bifunctional DNA helicase and F-box protein characterized by its DNA-dependent ATPase and 3'-5' DNA unwinding activities, as well as its role as a component of the SKP1–CUL1–F-box (SCF) E3 ubiquitin ligase complex[1][2][5]. FBH1 regulates homologous recombination by targeting and promoting the dissolution of RAD51 filaments at stalled DNA replication forks, thereby restricting hyper-recombination and preventing chromosomal instability[1][2][3][5]. As part of the cellular response to replication stress, FBH1 can promote double-strand break formation in concert with other nucleases like MUS81 and can trigger apoptosis in cells with severe replication stress, providing a tumor suppressor-like function[1][2][3]. FBH1 mutations or loss have been linked to a higher frequency of DNA repair defects, genomic instability, and increased cancer risk, including associations with certain melanomas and cancer predisposition syndromes[1][3][5]. No currently available drugs are known to act directly on FBH1.

Other names

FBXO18Fbx18hFBH1FLJ14590DNA 3'-5' helicase 1F-box only protein 18F-box only protein, helicase, 18F-box protein, helicase, 18