F-box only protein 30 (FBXO30)

F-box only protein 30 (FBXO30) is a member of the F-box protein family, defined by a ~40 amino acid F-box motif that enables assembly into the SCF (SKP1-CUL1-F-box) E3 ubiquitin ligase complex[3][4][6]. As a substrate recognition component, FBXO30 directs the SCF complex to its specific targets for ubiquitination and subsequent proteasomal degradation. FBXO30 has established roles in modulating protein turnover—including degradation of retinoic acid receptor gamma (RARγ) and hypoxia-inducible factor 1-alpha (HIF-1α)—thereby impacting BMP signaling, cell division, neural development, and muscle atrophy following denervation[1][2][6]. In cancer biology, FBXO30 has been characterized as a tumor suppressor in clear cell renal cell carcinoma and is dysregulated in nasopharyngeal and prostate cancer. Additionally, its expression and function are implicated in the regulation of mitosis, chromosome segregation, and susceptibility to neural tube defects[1][2]. Most research supports FBXO30 as a protein of emerging interest in ubiquitin-mediated proteolysis and cellular homeostasis.

Other names

F-box protein 30FBXO30FBX30MGC21674Fbx30F-box domain proteinF-box only proteinhelicase 18

Drugs or molecules targeting FBXO30 would likely modulate degradation of its substrates via the ubiquitin-proteasome pathway, potentially influencing processes such as cell cycle, proliferation, differentiation, neural development, and tumorigenesis[1][2][6].