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Target intelligence / Profile preview
F-box only protein 47 (FBXO47)
- Target
- FBXO47
- Molecular classification
- F-box protein family, Component of the SCF (Skp1-Cullin1-F-box protein) E3 ubiquitin ligase complex, Other (does not fit into established categories like receptor, ion channel, transporter, enzyme, or transcription factor)
01
Overview
F-box only protein 47 (FBXO47) is a meiotic F-box protein that belongs to the SCF (Skp1–Cullin1–F-box) E3 ubiquitin ligase complex family, functioning in the regulation of meiotic chromosome dynamics. FBXO47 is highly expressed in the testis and plays a critical role in male meiosis, specifically in mediating the attachment of telomeres to the inner nuclear envelope, facilitating homologue pairing, and maintaining proper centromere pairing and synapsis during prophase I. FBXO47 interacts with key meiotic proteins such as SKP1 and members of the telomeric shelterin complex (TRF2, TRF1), stabilizing these proteins and preventing their degradation, which is essential for telomere function and proper chromosome segregation. Disruption of Fbxo47 in mice results in defective synapsis, impaired double-strand break repair, failure of meiotic recombination, and male infertility. There are currently no drugs that target FBXO47, and it is not considered a clinical therapeutic target.
- Other names
- F-box protein 47FBXO47F-box only protein 47
02
Mechanism of action
Not applicable; no drugs or tool compounds described.
03
Biological functions
Regulation of centromere pairing and synapsis during meiosisStability, localization, and function of meiotic telomeresRegulation of telomere-inner nuclear envelope integration and bouquet formation in meiotic cellsPromotion of proper double-strand break (DSB) repair and progression through meiotic prophaseStabilization and interaction with SKP1 and telomere-associated proteins (e.g., TRF2) via modulation of protein ubiquitinationRegulation of HORMAD1 degradation through the ubiquitin–proteasome system in meiosis
04
Disease associations
Male infertility (knockout in mice leads to meiotic arrest and sterility)Meiotic defects (chromosome synapsis failure, impaired recombination, pachytene arrest)
05
Safety considerations
None specifically identified, as there are no drugs targeting FBXO47 and it is not proposed as a therapeutic target.
06
Interacting drugs
None reported. No small-molecule drugs or clinical agents currently target FBXO47
07
Biomarkers
None reported for patient selection or monitoring.
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