F-box protein 2 (FBXO2)

F-box protein 2 (FBXO2) is a cytoplasmic, neuron-enriched substrate recognition component of the SCF (SKP1-Cullin1-F-box protein) E3 ubiquitin-protein ligase complex, best known for its selective recognition and binding of high-mannose N-linked glycoproteins[1][2][7]. By targeting these glycoproteins for ubiquitination and subsequent proteasomal degradation, FBXO2 maintains glycoprotein quality control, plays a major role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins, and regulates processes such as synaptic plasticity, cell cycle progression, and metabolic signaling[1][2][5][7]. It is highly expressed in the nervous system, where it influences neuronal maintenance and plasticity, but also has emerging roles in the pathology of cancer and metabolic disease, with aberrant expression associated with tumor growth, neurodegeneration (including Alzheimer’s disease), and insulin resistance[1][2][5][7].

Other names

F-box only protein 2FBXO2FBX2NFB42Fbs1Fbg1FBG1OCP1F-box gene 1organ of Corti protein 1

Targeting high-mannose glycoproteins for ubiquitination and proteasomal degradation via SCF (SKP1-Cullin1-F-box) E3 ubiquitin ligase complexes[1][2][5] - Regulation of endoplasmic reticulum-associated degradation (ERAD) pathway for misfolded glycoproteins[7] - Modulation of major signaling and cell cycle pathways through protein degradation