F-box protein 22 (FBXO22)

F-box protein 22 (FBXO22) is a substrate recognition component of SCF (SKP1-cullin-F-box) type E3 ubiquitin ligase complexes, essential for targeting specific proteins for ubiquitin-mediated proteasomal degradation. It plays critical roles in controlling cell cycle progression, transcriptional regulation, DNA repair, apoptosis, epigenetic modification (regulating histone methylation via KDM4A), and cellular senescence. FBXO22’s activity influences cancer progression by promoting tumor cell proliferation but suppressing EMT and metastasis (notably through SNAIL degradation in a GSK3β-dependent manner). It also regulates oxidative stress responses by targeting BACH1 for degradation and modulates mTOR signaling during amino acid starvation. FBXO22 is deregulated in various cancers and is being investigated as both a prognostic biomarker and a therapeutic target. Mutations affecting the F-box domain (e.g., W52R) have been linked to increased cancer metastasis and therapeutic resistance.

Other names

F-box only protein 22FBX22FISTC1F-box protein FBX22p44FIST domain containing 1TYMAS

Not applicable directly; drugs would act by modulating E3 ligase activity, substrate recognition, or downstream proteasomal degradation. Potential mechanism via inhibition or enhancement of FBXO22–mediated degradation of specific substrates (e.g., SNAIL, BACH1).