F-box protein 25 (FBXO25)

F-box protein 25 (FBXO25) is a nuclear E3 ubiquitin ligase belonging to the F-box protein family, specifically the Fbxs class. It functions as the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ligase complex, mediating phosphorylation-dependent ubiquitination of target proteins for proteasomal degradation. FBXO25 is enriched in unique nuclear compartments called FBXO25-associated nuclear domains (FANDs), which are dynamic and influenced by transcriptional activity. It is broadly expressed, most strongly in the central nervous system, with proposed roles in protein quality control and regulation of nuclear protein aggregation—especially in preventing aggregation of pathogenic polyglutamine-containing proteins such as mutant huntingtin. Gene variants and altered expression have been associated with several disease states, including neurodegenerative disease, cancer, inflammation, immunological disorders, and certain developmental disorders[1][2][3][5].

Other names

F-box only protein 25FBXO25FBX25F-box protein Fbx25

Recruitment of substrates to the SCF E3 ubiquitin ligase complex for ubiquitination and subsequent proteasomal degradation Regulation of nuclear protein aggregation (notably polyglutamine-containing huntingtin)