F-box protein 38 (FBXO38)

F-box protein 38 (FBXO38) is a substrate recognition component of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase complex, responsible for the targeted ubiquitination and proteasomal degradation of select substrates. It was initially identified as a coactivator of the transcription factor KLF7 and is involved in neuronal development, spermatogenesis, and centromere integrity by targeting proteins ZXDA and ZXDB for degradation. FBXO38 has been reported to regulate immune checkpoint protein PD-1 in some studies; however, this role is disputed and considered unconfirmed by recent research. Mutations in the FBXO38 gene are linked to early-onset motor neuron diseases and other pathologies such as chronic inflammatory diseases. There are currently no drugs directly targeting FBXO38, and its role as a therapeutic target remains unestablished.

Other names

F-box only protein 38MoKASP329FLJ13962HMN2DHMND6modulator of KLF7 activity homologFBXO38

Not applicable—no specific drugs are documented to target FBXO38 in clinical or preclinical studies