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Target intelligence / Profile preview
F-box protein 39 (FBXO39)
- Target
- FBXO39
- Molecular classification
- F-box protein, Cancer-testis antigen (CTA)
01
Overview
FBXO39 (F-box protein 39) is a cancer-testis antigen (CTA) that is normally expressed in immune-privileged tissues such as the testis, but is aberrantly expressed in various cancer types. It belongs to the F-box family and plays roles in regulating cellular functions including proliferation, apoptosis, and immune responses. It functions as an oncogene, promoting cell proliferation, inhibiting apoptosis, and enhancing stemness and aggressiveness in cancer cells.
- Other names
- F-box only protein 39
02
Mechanism of action
Inhibition of FBXO39 reduces cancer cell proliferation and promotes apoptosis
03
Biological functions
Cell proliferationApoptosis regulationStemness regulationProtein ubiquitination (likely)Immune response (potential)
04
Disease associations
CancerGliomaColon cancerOsteosarcoma
05
Safety considerations
Off-target effects due to involvement in essential cellular processes (ubiquitination)
06
Biomarkers
Diagnostic biomarker for colon cancer and other malignanciesPrognostic biomarker for glioma (high expression correlates with poor survival)Tumor grade classification in glioma
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