F-box protein 44 (FBXO44)

F-box protein 44 (FBXO44) is a substrate recognition subunit of the SCF (SKP1-CUL1-F-box protein) and CRL4B (CUL4B-DDB1-F-box protein) E3 ubiquitin ligase complexes, facilitating the ubiquitination and proteasomal degradation of specific substrates. Unlike other FBA family members, FBXO44 does not bind glycosylated proteins but instead recognizes substrates including BRCA1, a key regulator of DNA repair and cell cycle control, and RGS2, a regulator of G-protein signaling. FBXO44 plays critical roles in cellular protein turnover and is implicated in diseases such as breast and ovarian cancer (via BRCA1 regulation) and hypertension and anxiety (via RGS2 regulation). Although no approved drugs are known to target FBXO44 directly, its involvement in disease-associated pathways makes it an attractive therapeutic target.

Other names

F-box only protein 44FBG3FBX30FBX6AFBXO6AMGC14140Fbxo6aFbx44F-box protein FBX30F-box/G-domain protein 3F-box gene 3

Drugs targeting FBXO44 would act by inhibiting its E3 ligase catalytic activity, thereby preventing the ubiquitination and degradation of target proteins such as RGS2 and BRCA1