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Target intelligence / Profile preview
F1 Capsular Antigen of Yersinia pestis (F1 antigen)
- Target
- F1 antigen
- Molecular classification
- Capsular Polysaccharide, Virulence Factor, Protein
01
Overview
The F1 capsular antigen is a major surface component of *Yersinia pestis*. It forms a capsule-like structure around the bacterium, which is highly expressed at mammalian body temperature. The primary function of the F1 antigen is to inhibit phagocytosis by host immune cells, particularly macrophages. It achieves this by interfering with complement-mediated opsonization, thereby helping *Y. pestis* evade innate immune responses during infection. Detection of circulating F1 antigen serves as an important diagnostic marker for plague.
- Other names
- Fraction 1 antigenCapsule antigenYPMT_084Y1100YP_pMT082cafI
02
Mechanism of action
Inhibits complement-mediated opsonization, thereby preventing phagocytosis by immune cells.
03
Biological functions
AntiphagocytosisImmune evasionAdhesionOpsonization Inhibition
04
Disease associations
PlagueYersiniosisInfection
05
Safety considerations
Potential for immunogenicity issues in vaccine development.Variations in efficacy depending on host genetic background.
06
Biomarkers
Circulating F1 antigen in serumF1 antigen in urineF1 antigen in buboes
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