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Target intelligence / Profile preview
Facilitates Chromatin Transcription Complex (FACT)
- Target
- FACT
- Molecular classification
- Histone Chaperone, Chromatin Remodeling Complex
01
Overview
The Facilitates Chromatin Transcription (FACT) complex is a heterodimeric protein complex consisting of SUPT16H and SSRP1. It functions as a histone chaperone, playing a crucial role in chromatin remodeling during transcription, DNA replication, and DNA repair. FACT destabilizes nucleosomes to facilitate the passage of RNA polymerase II and other enzymes through chromatinized DNA templates. Overexpression of FACT is associated with aggressive cancers, while defects can lead to intellectual disability syndromes.
02
Mechanism of action
Inhibition of FACT complex
03
Biological functions
Transcription ElongationDNA ReplicationDNA RepairChromatin RemodelingHistone Binding
04
Disease associations
CancerIntellectual Disability Syndromes
05
Safety considerations
Potential for broad effects on transcription and DNA replicationToxicity to rapidly dividing cellsOff-target effects due to ubiquitous expression (though limited in adult tissues)
06
Biomarkers
FACT expression levels in tumor tissue
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