FACT complex subunit SPT16 (SUPT16H)

FACT complex subunit SPT16 (SUPT16H) is the large subunit of the FACT (Facilitates Chromatin Transcription) complex, an evolutionarily conserved histone chaperone involved in reorganizing nucleosomes to permit access for transcription, DNA replication, and DNA repair machinery[1][2][3]. SUPT16H binds to histones H2A/H2B and H3/H4, mediating nucleosome disassembly during RNA polymerase II transcription elongation and then restoring chromatin structure post-transcription[1][2][3]. Loss-of-function variants in SUPT16H are associated with severe developmental disorders, including neurodevelopmental delay, intellectual disability, and epilepsy[3]. The gene is expressed ubiquitously and is essential for cell growth and survival[3]. No clinically approved drugs specifically target SUPT16H, and it is not currently known to be used as a biomarker or for therapeutic targeting, though its pivotal cellular functions make it an emerging point of interest in chromatin regulation research[1][2][3][4].

Other names

SPT16 homolog, facilitates chromatin remodeling subunitFACT complex subunit SPT16FACT140FACTP140hSPT16FACTSPT16/CDC68FLJ14010FLJ10857CDC68Chromatin-specific transcription elongation factor 140 kDa subunitFacilitates chromatin transcription complex subunit SPT16Facilitates chromatin remodeling 140 kDa subunitNEDDFACSPT16suppressor of Ty 16 homolog