Neisseria meningitidis group B recombinant protein antigen

The "Neisseria meningitidis group B recombinant protein antigen" refers to a set of purified, genetically-engineered bacterial proteins used as antigenic components in vaccines against the group B strain of Neisseria meningitidis, a major cause of bacterial meningitis and sepsis. The most studied and widely-used recombinant antigens are factor H binding protein (fHbp), Neisserial adhesin A (NadA), and Neisserial heparin binding antigen (NHBA). These are found on the bacterial outer membrane, contribute to pathogenesis through immune evasion or cell adhesion, and are recognized by the human immune system, eliciting protective antibody responses when used in vaccines such as Bexsero. Recombinant protein antigen-based vaccines offer broad protection by including multiple conserved targets, and their efficacy depends on the conservation, surface expression, and immunogenicity of these proteins among circulating bacterial strains.

Other names

4CMenB vaccine protein antigensBexsero antigensNeisseria meningitidis group B vaccine recombinant proteinsNHBANadAfHbpfactor H binding proteinNeisseria adhesin ANeisseria heparin binding antigenGNA2132 (NHBA)GNA1870 (fHbp)GNA1994 (NadA)

Induction of bactericidal antibodies via complement-mediated killing (NHBA, NadA, fHbp); Immune memory generation (vaccination effect)