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Thrombin (None)
- Target
- None
- Molecular classification
- Enzyme, Serine Protease
01
Overview
Thrombin, also known as coagulation factor IIa, is a serine protease enzyme that plays a central role in the blood coagulation cascade. It is responsible for converting soluble fibrinogen into insoluble fibrin strands, which are essential for clot formation and hemostasis. It also activates platelets and other coagulation factors, amplifying the clotting process and is involved in wound healing.
- Other names
- Factor IIafibrosethrombasethromboforttopical thrombin-Ctropostasinactivated blood-coagulation factor IIE thrombinbeta-thrombingamma-thrombin
02
Mechanism of action
Thrombin inhibitors directly or indirectly block the activity of thrombin, preventing the conversion of fibrinogen to fibrin and subsequent clot formation.
03
Biological functions
HemostasisBlood coagulationWound healingPlatelet activation
04
Disease associations
ThrombosisBleeding disorders
05
Safety considerations
Bleeding riskThrombocytopeniaHypersensitivity reactions (to bovine-derived thrombin)Risk of paradoxical thrombosis with certain agents
06
Interacting drugs
Heparin
2 more in the full profile.
07
Biomarkers
Prothrombin time (PT)Activated partial thromboplastin time (aPTT)Thrombin time (TT)D-dimer
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