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Target intelligence / Profile preview
Factor IX (FIX)
- Target
- FIX
- Molecular classification
- Serine protease, Vitamin K-dependent protein
01
Overview
Factor IX, also known as Christmas factor, is a vitamin K-dependent plasma glycoprotein and a serine protease that plays a crucial role in the intrinsic pathway of blood coagulation. It is synthesized in the liver and circulates in the bloodstream as an inactive zymogen until activated by factor XIa following vascular injury. Mutations or deficiencies in F9 cause hemophilia B—a hereditary bleeding disorder characterized by impaired blood clotting leading to excessive bleeding after injuries or surgery.
- Other names
- Christmas factorPlasma thromboplastin component (PTC)HEMBTHPH8
02
Mechanism of action
Replaces deficient Factor IX, enabling proper blood clot formation
03
Biological functions
HemostasisBlood coagulationActivation of Factor X
04
Disease associations
Hemophilia B
05
Safety considerations
Thrombotic eventsDevelopment of inhibitors (antibodies) against Factor IXAnaphylaxis
06
Interacting drugs
Benefix
3 more in the full profile.
07
Biomarkers
Factor IX activity levelFactor IX antigen level
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