Target intelligence / Profile preview

Coagulation Factor V (FV)

Target: FV
Molecular classification: Glycoprotein, Coagulation Factor, Enzyme Cofactor

Overview

Coagulation factor V (Factor V, proaccelerin, or labile factor) is a glycoprotein that plays a dual role in the blood coagulation system, acting as both a procoagulant and an anticoagulant. It is essential for thrombin generation and is regulated by activated protein C (APC). The Factor V Leiden mutation, a common cause of thrombophilia, results in resistance to APC inactivation, increasing the risk of blood clots.

Other names: Factor VProaccelerinLabile Factor

Mechanism of action

Factor V is a cofactor in the prothrombinase complex, essential for thrombin generation. Activated Protein C (APC), with Protein S, degrades/inactivates Factor Va.

Biological functions

Blood coagulationThrombin generationRegulation of coagulationAPC cofactor

Disease associations

ThrombophiliaDeep vein thrombosisPulmonary embolismBleeding disorders

Safety considerations

Increased risk of thrombosis (e.g., with Factor V Leiden)Bleeding risk (in Factor V deficiency)Drug interactions with anticoagulants

Interacting drugs

Anticoagulants (e.g., Warfarin, Heparin, Direct Oral Anticoagulants)

1 more in the full profile.

Biomarkers

Factor V Leiden mutation (Arg506Gln)Factor V activity levelsAPC resistance

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