Target intelligence / Profile preview

Factor VIIIa (FVIIIa)

Target: FVIIIa
Molecular classification: Coagulation factor, Serine protease cofactor

Overview

Factor VIIIa is the activated form of coagulation factor VIII, a crucial protein in the blood clotting cascade. It acts as a cofactor for factor IXa, enabling efficient activation of factor X to Xa, which is essential for thrombin generation and subsequent fibrin clot formation.

Other names: Activated Factor VIII

Mechanism of action

Cofactor for FIXa, enabling rapid FX to FXa conversion.

Biological functions

HemostasisBlood coagulationCofactor activity

Disease associations

Hemophilia A

Safety considerations

Immunogenicity (development of inhibitors)Thrombosis (in some cases of replacement therapy)

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