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Target intelligence / Profile preview
Factor Xa Inhibitor (FXa Inhibitor)
- Target
- FXa Inhibitor
- Molecular classification
- Enzyme Inhibitor, Small Molecule Inhibitor
01
Overview
Factor Xa inhibitors are a class of anticoagulant drugs that selectively and reversibly inhibit the activity of clotting factor Xa, a key enzyme in the coagulation cascade. By blocking factor Xa, these agents prevent the conversion of prothrombin to thrombin, ultimately inhibiting fibrin clot formation. They are used for the treatment and prevention of thromboembolic disorders, including deep vein thrombosis, pulmonary embolism, and stroke prevention in atrial fibrillation.
- Other names
- Direct Factor Xa InhibitorsXabansDirect Oral Anticoagulants (DOACs) targeting Factor Xa
02
Mechanism of action
Selective and reversible inhibition of the active site of coagulation factor Xa, preventing the conversion of prothrombin to thrombin and subsequent fibrin clot formation.
03
Biological functions
AnticoagulationThrombin InhibitionBlood Coagulation Regulation
04
Disease associations
ThrombosisPulmonary EmbolismAtrial FibrillationVenous ThromboembolismCardiovascular Disease
05
Safety considerations
Bleeding risk (intracranial hemorrhage, gastrointestinal hemorrhage)Drug interactions (CYP450 enzymes, P-glycoprotein)Need for reversal agents (e.g., andexanet alfa) in case of uncontrollable bleeding
06
Interacting drugs
Apixaban
6 more in the full profile.
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