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Target intelligence / Profile preview
Factor XIIIa (FXIIIa)
- Target
- FXIIIa
- Molecular classification
- Enzyme, Transglutaminase
01
Overview
Factor XIIIa, also known as fibrin-stabilizing factor or FXIIIa, is the active form of Factor XIII, a transglutaminase enzyme crucial for blood coagulation. It catalyzes the formation of covalent crosslinks between fibrin molecules in blood clots, thereby stabilizing them and making them resistant to premature breakdown (fibrinolysis). Beyond hemostasis, FXIIIa plays roles in wound healing by promoting fibroblast proliferation and inhibiting apoptosis. It also participates in angiogenesis during embryonic development and tissue repair processes.
- Other names
- Fibrin-stabilizing factorF13A
02
Mechanism of action
Crosslinking fibrins via ε-(γ-glutamyl)lysyl bonds, strengthening clots and making them resistant to fibrinolysis.
03
Biological functions
Clot stabilizationWound healingAngiogenesisTissue repair
04
Disease associations
Bleeding disordersAbnormal wound healing (e.g., keloids)Tumor biology
05
Safety considerations
Deficiency leads to bleeding disordersOverexpression or altered function implicated in abnormal wound healing and tumor biology
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