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FAM13A antisense RNA 1 (FAM13A-AS1)
- Target
- FAM13A-AS1
- Molecular classification
- Long non-coding RNA, Non-protein coding RNA, Other
01
Overview
FAM13A antisense RNA 1 (FAM13A-AS1) is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the FAM13A locus. FAM13A-AS1 does not code for a protein but regulates cellular processes through interactions with microRNAs and other RNAs. It acts as a competing endogenous RNA (ceRNA), such as sponging miR-141-3p to upregulate NEK6 expression in renal cell carcinoma, thereby promoting cell proliferation, migration, invasion, and inhibiting apoptosis[2]. Elevated expression of FAM13A-AS1 has been associated with poor prognosis and advanced tumor features in several cancers, including renal cell carcinoma and cervical cancer[2][3]. It is emerging as a potential biomarker and possible therapeutic target in oncology, although no direct small-molecule or antibody drugs currently target this lncRNA[2][6]. FAM13A-AS1 is primarily cytoplasmic, regulating gene expression post-transcriptionally by interacting with specific microRNAs, and is implicated in multiple tumorigenic processes and potentially other disease pathways[2][3][6].
- Other names
- NCRNA00039non-protein coding RNA 39FAM13A1OSFAM13AOS
02
Biological functions
Regulation of cell proliferationRegulation of cell migrationRegulation of cell invasionRegulation of apoptosisCompeting endogenous RNA (ceRNA) activitymiRNA sponge
03
Disease associations
Cancer, specifically renal cell carcinomacervical cancernon-small cell lung carcinomabladder urothelial carcinomaneuroblastoma
04
Biomarkers
Prognostic biomarker for renal cell carcinomathyroid cancerused in multi-lncRNA prognostic signatures for bladder urothelial carcinoma
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