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Target intelligence / Profile preview
FAM167A antisense RNA 1 (FAM167A-AS1)
- Target
- FAM167A-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), RNA gene
01
Overview
FAM167A antisense RNA 1 (FAM167A-AS1) is a long non-coding RNA gene located on human chromosome 8 (gene symbol: FAM167A-AS1, HGNC ID: 15548, NCBI ID: 83656). It is transcribed from the opposite strand to the FAM167A gene and is classified as an lncRNA, meaning it does not code for protein but can regulate gene expression post-transcriptionally and epigenetically. Several pathogenic alleles and variants have been identified, with associations to diseases such as glioma susceptibility and osteonecrosis of the jaw. Like other antisense lncRNAs, FAM167A-AS1 may modulate expression of nearby genes, participate in chromatin modification, or impact mRNA stability, although its exact biological roles and functional mechanisms remain to be fully elucidated. No drugs, biomarkers, or safety concerns are currently linked to this RNA, and it is not considered a canonical therapeutic target as defined by protein receptors, enzymes, or transporters.
- Other names
- FAM167A-AS1C8orf12FAM167A antisense gene protein 1 (misleading, since it is an RNA, not a protein)Uncharacterized protein FAM167A-AS1 (misleading, as above)FAM167A antisense RNA 1
02
Mechanism of action
Not applicable (no drugs targeting FAM167A-AS1 are known)
03
Biological functions
Regulatory RNA: lncRNAs like FAM167A-AS1 are implicated in gene regulation, especially via modulation of mRNA stability, chromatin remodeling, and transcriptional regulationModulation of cognate sense gene expression (often via antisense lncRNAs)Stabilization or degradation of target mRNAActing as scaffolds for chromatin modifiers or RNA-binding proteins
04
Disease associations
Cancer (Glioma Susceptibility 1)Osteonecrosis of the jawPossibly associated with copy number variation syndromes such as 8p23.1 CNV syndromeAntisense lncRNAs broadly have known roles in cancer progression and gene regulation (though explicit disease roles for FAM167A-AS1 beyond those listed await further research)
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