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Target intelligence / Profile preview
FAM53B antisense RNA 1 (FAM53B-AS1)
- Target
- FAM53B-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
FAM53B antisense RNA 1 (FAM53B-AS1) is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the FAM53B locus. It is classified as an antisense RNA and like other antisense lncRNAs, may have regulatory roles in gene expression, potentially by influencing its sense counterpart (FAM53B) through transcriptional interference, chromatin modification, or stabilization/destabilization of sense mRNA[2][3]. No direct evidence currently links FAM53B-AS1 to specific biological pathways, diseases, or therapeutic targeting. Its gene is cataloged in multiple databases under the aliases listed above[3]. While the FAM53B sense gene plays a role in transcriptional regulation, cell proliferation, and the Wnt signaling pathway (notably in leukemia), there is no published functional characterization or disease association specific to the antisense transcript FAM53B-AS1[1][3].
- Other names
- FAM53B-AS1HGNC:49499NCBI Gene:101927944Ensembl:ENSG00000233334GC10P126398GC10P124703
02
Biological functions
Regulation of gene expression (likely by modulating sense gene FAM53B, based on general functions of antisense lncRNAs)Transcriptional regulation (by analogy to other antisense lncRNAs)Possible involvement in cell proliferation and differentiation (inferred from related sense gene FAM53B functions)
03
Disease associations
Other (No specific disease association for FAM53B-AS1 identified; however, FAM53B is implicated in leukemia)
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