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Family-18 Chitinases
- Molecular classification
- Enzyme, Glycoside Hydrolase
01
Overview
Family-18 chitinases are enzymes classified within the glycoside hydrolase family 18 (GH18), a large group of proteins found across archaea, prokaryotes, and eukaryotes. These enzymes primarily catalyze the hydrolysis of β-1,4-glycosidic bonds in chitin. They are involved in diverse physiological roles depending on the organism, including tissue remodeling, immune response regulation, and pathogenesis. Notable human GH18 members include chitotriosidase (CHIT1), acidic mammalian chitinase (AMCase), CHI3L1/YKL40, and CHI3L2/YKL39.
- Other names
- Glycoside Hydrolase Family 18GH18 chitinasesGH18
02
Mechanism of action
Catalyzes the hydrolysis of β-1,4-glycosidic bonds in chitin using a substrate-assisted retaining mechanism.
03
Biological functions
Chitin hydrolysisTissue remodelingImmune response regulationPathogenesisNutrition uptakeEmbryonic development
04
Disease associations
Inflammatory diseasesAllergyInfectionCancer (potential biomarker)
05
Biomarkers
CHI3L1/YKL40CHI3L2/YKL39
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