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Family with sequence similarity 107 member B (FAM107B)
- Target
- FAM107B
- Molecular classification
- Other (protein-coding gene with a conserved domain of unknown function, DUF1151; not a receptor, enzyme, transporter, ion channel, or transcription factor by established criteria), Part of the FAM107 protein family (with paralog FAM107A), Putative heat shock-inducible protein (low molecular weight heat shock family)
01
Overview
Family with sequence similarity 107 member B (FAM107B) is a protein-coding gene located on human chromosome 10p13, expressed in most tissues and development stages. Its protein contains a conserved N-terminal domain (DUF1151) with unclear molecular function, and a unique C-terminal region, contributing to a low molecular weight form known as heat shock-inducible tumor small protein (HITS). Expression of FAM107B is notably reduced or lost in various cancers, with evidence supporting its role as a candidate tumor suppressor gene. Its molecular mechanisms are incompletely understood but may involve chromatin modification, gene transcription regulation, and potentially cell migration. FAM107B is highly conserved across species and has a paralog (FAM107A) with related but distinct biological actions. No drugs directly target FAM107B, and it is considered a marker rather than a therapeutic target.
- Other names
- FAM107BC10orf45FLJ45505MGC11034MGC90261HITS (Heat shock-inducible tumor small protein)Protein FAM107BFAM107B/CDNF fusion (rare, possibly context-specific)Heat shock-inducible tumor small protein
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Mechanism of action
None reported; as there are no recognized drugs, mechanisms of action are not defined
03
Biological functions
May modulate chromatin structure and gene transcriptionPotential involvement in cytoskeletal reorganization and cell migration (based on paralog FAM107A)Expressed throughout development; in most tissues including neural cellsSensory perception of sound (predicted role)Possible involvement in stress response, especially to heat shock
04
Disease associations
Cancer (expression lost or downregulated in gastrointestinal, colorectal, gastric, breast, thyroid, testicular, uterine cervical cancers)Tumor suppressor function (proposed, based on inhibitory effects on tumor growth upon restoration of expression)Carpal tunnel syndrome 2 (associative, reported in gene set data)Intracranial vasospasm (associative, reported in gene set data)
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Safety considerations
None specifically reported. As FAM107B is not a validated drug target, therapeutic safety issues are not defined
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Biomarkers
Potential as a pathological marker in cancer diagnosis and prognosis (especially gastrointestinal, breast, and thyroid tumors due to expression patterns)No established use as a drug-response biomarker
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