Family with sequence similarity 110 member C (FAM110C)

Family with sequence similarity 110 member C (FAM110C) is a cytoplasmic protein primarily involved in regulating the organization of the microtubule cytoskeleton and cellular processes related to migration and spreading[1][3][5]. FAM110C binds alpha-tubulin and is located in the cell cortex, associating with centrosomes during interphase and with microtubules during mitosis[2][6]. It is transiently upregulated during the periovulatory period in granulosa cells, where its overexpression leads to G1 cell cycle arrest but does not affect steroidogenic function, suggesting a role in granulosa cell differentiation rather than steroid hormone production[2]. FAM110C also interacts with AKT1, and depletion of the protein impairs integrin-mediated formation of filopodia and cell migration, likely involving PI3K/AKT1 signaling pathways[1][5]. FAM110C is not a therapeutic target, but it is of interest in cell biology and developmental studies for its role in cell cycle regulation and differentiation.

Other names

Protein FAM110CFAM110C

No drug mechanisms of action are established for this protein, as it is not pharmacologically targeted.