Family with sequence similarity 114 member A1 (FAM114A1)

Family with sequence similarity 114 member A1 (FAM114A1), also known as Protein NOXP20, encodes a cytoplasmic protein implicated in neuronal cell development and the regulation of melanocyte biology, particularly apoptosis, proliferation, and melanin synthesis[1][2][3]. FAM114A1 contains a caspase recruitment domain and is most abundantly expressed in the nervous system, as well as in the embryonic and adult brain[1]. It exerts a regulatory influence in various cell types including melanocytes and immune cells, and may act through the modulation of RACK1, an intracellular adaptor protein, particularly in controlling apoptosis in melanocytes[1][2]. Genetic and expression studies suggest roles in multiple diseases, including pigmentary disorders (vitiligo), autoimmune diseases (ankylosing spondylitis, autoimmune enteritis), liver fibrosis, and some cancers, where its expression serves as a prognostic biomarker[2]. The protein is multifaceted, but there is currently no evidence it functions as a typical druggable therapeutic target such as a receptor or enzyme[1][2][3][4][5].

Other names

Protein NOXP20NOXP20Nervous system overexpressed protein 20Noxp20Nervous system over-expressed protein 20