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Target intelligence / Profile preview
Family with sequence similarity 114 member A2 (FAM114A2)
- Target
- FAM114A2
- Molecular classification
- Other
01
Overview
Family with sequence similarity 114 member A2 (FAM114A2) is a protein-coding gene located on chromosome 5 (5q31-33) in humans[3]. The protein is 505 amino acids in length with a molecular weight of approximately 55.5 kDa and an isoelectric point of 4.66[3][7]. It is predicted to localize to the nucleus after translation[3]. FAM114A2 is highly expressed in most tissues, including brain tissue, and is well conserved among mammals and other species (e.g., mice, cows, primates)[3][5]. The protein may possess purine nucleotide binding activity and structural features suggest involvement in ATP- or GTP-binding, but its precise biological function remains unclear[5][3]. FAM114A2 is not currently considered a therapeutic target, lacks credible evidence for drug interactions, and is not commonly referenced as a biomarker or safety concern[5][3][2]. Some genetic associations with rare congenital diseases are reported, but direct mechanistic links are lacking[5].
- Other names
- C5orf3protein FAM114A2133K02testis tissue sperm-binding protein Li 81P
02
Mechanism of action
None reported; no drugs known to target FAM114A2
03
Biological functions
Purine nucleotide binding (predicted)Possible involvement in ATP- and/or GTP-binding due to a P loop motif (suggested by protein structure prediction)
04
Disease associations
Isolated ectopia lentis (association)Congenital contractural arachnodactyly (association)No direct evidence for roles in major diseases such as cancer, inflammation, or neurodegenerative disease, though the gene is expressed in various cancers
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