Family with sequence similarity 117 member B (FAM117B)

Family with sequence similarity 117 member B (FAM117B) is a cytoplasmic protein characterized by an ETGE protein-protein interaction motif, enabling it to bind Kelch-like ECH-associated protein 1 (KEAP1) and compete with nuclear factor erythroid 2–related factor 2 (NRF2) for KEAP1 binding[1][3]. This competition reduces ubiquitination and proteasomal degradation of NRF2, resulting in increased NRF2 signaling—a pathway central to oxidative stress response, tumor development, and chemoresistance. FAM117B promotes gastric cancer cell growth and resistance to chemotherapy, is overexpressed in gastric tumors, and may have additional clinical significance based on genetic association with neurodegenerative (juvenile ALS), vascular, and immune-mediated diseases[1][2][3][4]. While currently not a target of any approved drugs, its role in malignancy and other disease contexts positions it as a candidate therapeutic target and biomarker for further research.

Other names

ALS2CR13Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13FLJ38771Protein FAM117BAmyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 13

Not applicable; no drugs are known to target this protein directly[1][3][4]