Family with sequence similarity 118 member B (FAM118B)

Family with sequence similarity 118 member B (FAM118B) is a protein-coding gene encoding a 34-kDa protein that primarily localizes in the nucleus, concentrating in Cajal bodies—a type of subnuclear structure involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing[1][2][3]. FAM118B interacts with core Cajal body components such as coilin and the SMN complex and is necessary for proper Cajal body assembly, splicing factor modification, and efficient pre-mRNA splicing[2]. Depletion of FAM118B disrupts Cajal body morphology, reduces splicing efficiency, and lowers cell proliferation, underscoring its importance in cell viability and nuclear RNA metabolism[2][3]. Although associated with certain cancer types, FAM118B is not currently characterized as a classical therapeutic target, such as a druggable enzyme or receptor[1][4].

Other names

FAM118BFLJ21103hFAM118Bprotein FAM118BFAM118BpA0A024R3L8E9PIM5