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Family with sequence similarity 122 member B (FAM122B)
- Target
- FAM122B
- Molecular classification
- Other (predicted serine/threonine phosphatase inhibitor)
01
Overview
Family with sequence similarity 122 member B (FAM122B), also known as PABIR2, is a protein encoded on human chromosome X. The protein is predicted to act as a serine/threonine phosphatase inhibitor, suggesting a regulatory function in phosphatase-mediated signaling pathways. It is also predicted to be a component of the collagen trimer, implying possible extracellular matrix or structural cell roles. In non-human models such as mice, the gene is named "synoviocyte proliferation-associated in collagen-induced arthritis 2," implicating potential involvement in inflammatory processes and cell proliferation in synovial tissues, although direct evidence of a therapeutic target role or disease causality in humans is lacking.
- Other names
- PABIR family member 2PABIR2DKFZp686L20116RP11-308B5.5SPACIA2synoviocyte proliferation-associated in collagen-induced arthritis 2protein FAM122Bfamily with sequence similarity 122B
02
Biological functions
Protein serine/threonine phosphatase inhibitor activitypredicted involvement in collagen trimer complex
03
Disease associations
Inflammation (notably synoviocyte proliferation in collagen-induced arthritis from mouse studies)possible but unconfirmed roles in human disease
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